Methylation is a process where certain nutrients called methyl donors’ are added to specific elements of DNA, our gene markers and proteins that keep them physiologically active. Methylation is a major pathway to focus on in understanding autoimmune and neurological diseases such as multiple sclerosis, seizure disorders, dementia, chronic fatigue syndrome, lupus, depression, anxiety and autism spectrum disorders. Methylation is responsible for making, maintaining and repairing DNA. The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of biochemical functions: detoxification, supporting DNA (turning genes on and off), producing energy, reducing inflammation, synthesising neurotransmitters, homocysteine metabolism, protein methylation, phase 2 liver detoxification and supporting immune function. Inadequate methylation capacity can lead to birth defects, depression, cognitive decline, and cancer. Impaired methylation has even been associated with autism. Support of methylation markers has been associated with rapid return of speech, improvement of behaviour in ADD and ADHD spectrums. Conditions Associated with Impaired Methylation:
- Chronic Fatigue Syndrome (CFS)
- Cognitive decline
- Cardiovascular disease
- High folate supplementation
- Infertility, pre-conception care
- Mental health disorders
- Oestrogen dominance
- MTHFR (methylenetetrahydrofolate reductase)
- MTR (5-methyltetrahydrofolate-homocysteine methyltransferase)
- MTRR (methionine synthase reductase)
- AHCY (Adenosylhomocysteinase),
- COMT (Catechol-O- methyltransferase)
How is The Sample Taken? This is a buccal swab test – a pathology test kit will be posted to you and they samples can be taken in the comfort of your own home. Simply take the swab sample, place it in the express prepaid envelope and pop in the the post box. The test kit contains full instructions.
Test Turnaround Time The standard turnaround time for this test is 7 – 10 working days from the date the patient’s specimen/s are received by NutriPath laboratory. What does the cost cover? The Emed website cost covers the processing of all information, samples and the interpretation and collation of final results into your personalised comprehensive report. Like to Know More? If you would like to know more about Emed MTHFR Gene Testing please contact your Emed practitioner today.