Description
A simple genetic test is the only way to find out if you have either or both of the identified variations in the MTHFR gene that affects how your body metabolises folate. If you have one of the gene variations it can result in low blood levels of folate, which can increase the risk of many health problems. Having a genetic test for folate metabolism is important for people with a history of heart and blood pressure vessel disease or with a history of anaemia. It is also important for women who are planning a pregnancy. What is Folate? Folate is one of the B-group vitamins and is an essential nutrient that your body needs to maintain good health. It is used for a range of functions including making and repairing DNA and producing healthy red blood cells. However it is probably best known for its role in helping to prevent neural tube defects such as spina bifid a in unborn babies. Folate is the name given to the natural food form of this vitamin. For folate to perform its important functions in the body, it must first be absorbed into the bloodstream. Your body produces the MTHFR enzyme to convert folate from the foods or supplements you eat into a form that can be readily absorbed into the bloodstream. This converted form of folate found in the blood is called serum folate. Your level of serum folate depends not only on how much folate you consume, but also on your body’s ability to convert or metabolise dietary folate to serum folate. People who don’t metabolise folate efficiently have low serum folate levels and an increased risk of heart and blood vessel disease, neural tube defects in unborn babies and other health problems. Genes and Folate Metabolism Your body produces the MTHFR enzyme to convert folate into serum folate and so it can be absorbed into your system. The MTHFR gene provides instructions for your body to make the MTHFR enzyme. Some people have variations in the MTHFR gene that cause the MTHFR enzyme to work less efficiently. People with one of these gene variations, have an increased risk of certain health problems; this risk is even greater if they also don’t get much folate through their diet. Did You Know? Variations in the MTHFR gene can reduce your ability to metabolise folate by up to 70%. Homocysteine and Folate Metabolism
- Inadequate folate intake leads to decreased serum folate levels. This decrease in serum folate leads to high homocysteine levels.
- Low levels of homcysteine in the body are good for health, however high levels may lead to an increased risk of health problems.
- High homocysteine levels can be reduced with increased folate and folic acid supplements. It is important to speak with your healthcare professional for recommendations on folate intake.
- Reduced activity of the MTHFR enzyme can cause an increase in homocysteine levels.
Who Should Have a Genetic Test for Folate Metabolism? Whether or not you have good folate absorption affects many different areas of your health. Therefore, having a genetic test for folate metabolism may be especially helpful for many people including:
- Women who are planning or in the early stages of pregnancy.
- People with a personal or family history of heart or blood vessel disease.
- People with a history of anaemia.
- Anyone who is interested in maintaining good health and preventing future health problems associated with low folate metabolism such as type 2 diabetes, obesity and mood disorders.
Having a simple genetic test is the only way of knowing if you have a variation in the MTHFR gene that can result in low serum folate. If you require any more information on this genetic test, speak to your Emed Practitioner today. Further Reading:
